Right Atrial Adaptation to Precapillary Pulmonary Hypertension: Pressure-Volume, Cardiomyocyte, and Histological Analysis.
Jeroen N WesselsJessie van WezenbeekJari de RoverRowan SmalAida Llucià-ValldeperasLucas R CelantJ Tim MarcusLilian J MeijboomJoanne A GroeneveldtFrank P T OosterveerToon A WinkelmanHans W M NiessenMarie-José GoumansHarm Jan BogaardAnton Vonk NoordegraafGustav J StrijkersM Louis HandokoBerend E WesterhofFrances S de ManPublished in: Journal of the American College of Cardiology (2023)
RA PV loops show increased RA stiffness and suggest atrioventricular uncoupling in patients with severe RV diastolic stiffness. Isolated RA cardiomyocytes of precPH patients are hypertrophied, without intrinsic sarcomeric changes. In end-stage precPH, reduced capillary density is accompanied by interstitial and perivascular fibrosis.
Keyphrases
- pulmonary hypertension
- rheumatoid arthritis
- ejection fraction
- end stage renal disease
- disease activity
- mycobacterium tuberculosis
- newly diagnosed
- chronic kidney disease
- blood pressure
- peritoneal dialysis
- ankylosing spondylitis
- pulmonary artery
- left ventricular
- atrial fibrillation
- pulmonary arterial hypertension
- heart failure
- systemic lupus erythematosus
- catheter ablation
- patient reported outcomes
- coronary artery
- systemic sclerosis