Tensile-Strained Palladium Nanosheets for Synthetic Catalytic Therapy and Phototherapy.
Shanshan LiBolong XuMingzhu LuMengxue SunHaokun YangShuang LiuZhijun HuangHuiyu LiuPublished in: Advanced materials (Deerfield Beach, Fla.) (2022)
Palladium nanosheets (Pd NSs) are well-investigated photothermal therapy agents, but their catalytic potential for tumor therapy has been underexplored owing to the inactive dominant (111) facets. Herein, lattice tensile strain is introduced by surface reconstruction to activate the inert surface, endowing the strained Pd NSs (SPd NSs) with photodynamic, catalase-like, and peroxidase-like properties. Tensile strain promoting the photodynamic and enzyme-like activities is revealed by density functional theory calculations. Compared with Pd NSs, SPd NSs exhibit lower photothermal effect, but approximately five times higher tumor inhibition rate. This work calls for further study to activate nanomaterials by strain engineering and surface reconstruction for catalytic therapy of tumors.
Keyphrases
- density functional theory
- reduced graphene oxide
- molecular dynamics
- cancer therapy
- quantum dots
- stem cells
- photodynamic therapy
- gold nanoparticles
- molecular dynamics simulations
- cell therapy
- crystal structure
- metal organic framework
- hydrogen peroxide
- mass spectrometry
- climate change
- mesenchymal stem cells
- high resolution
- replacement therapy