Microdialysis as a tool to determine the local tissue concentration of dicloxacillin in man.

Kristian Kraft HansenFlemming NielsenTore Bjerregaard StageUffe JørgensenOle SkovLasse E Rasmussen

Published in: British journal of clinical pharmacology (2017)

The unbound dicloxacillin concentration in adipose and muscle tissue remained above the MIC for sensitive S. aureus, for a period sufficient for many orthopaedic procedures. Whether this is true in patients with compromised circulation remains to be investigated.

Keyphrases

skeletal muscle
adipose tissue
insulin resistance
mass spectrometry
single molecule