Identification of an Activating PDGFRA Deletion in a Novel Sinonasal Soft Tissue Neoplasm.

James A WatkinsHelen HatcherShalini MalhotraFurrat AmenJonathan BrutyJamie TrotmanPatrick TarpeyJohn A Tadross

Published in: Head and neck pathology (2023)

We describe a novel sinonasal spindle cell tumour characterised by an activating insertion/deletion in exon 12 of PDGFRA. The diagnosis of PDGFRA-activated sinonasal spindle cell tumour should be considered in difficult to classify mesenchymal lesions at this site.

Keyphrases

single cell
soft tissue
cell therapy
signaling pathway
stem cells
bone marrow
low grade
bioinformatics analysis