Germline BRCA pathogenic variants in patients with ovarian cancer and post-poly (ADP-ribose) polymerase inhibitor myeloid neoplasms.

C ValenzaM MongilloF GigliD TrapaniJ KatriniE NicolòL BoldriniL Boscolo BieloG CastellanoL GuidiG PellizzariS DerioM LapresaG ParmaE DerenziniG CuriglianoN Colombo

Published in: ESMO open (2024)

The presence of a gBRCA-PV is associated with a higher risk of MDS-pCT and possibly of myeloid neoplasms after PARPi in patients with aHGOC who received PARPi, especially in the setting of recurrent disease.

Keyphrases

dendritic cells
bone marrow
acute myeloid leukemia
copy number
dna repair
gene expression
immune response
oxidative stress
structural basis
genome wide