Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networks.

Eric J FishKristopher J IrizarryPatricia DeInnocentesConnor J EllisNripesh PrasadAnthony G MossR Curt Bird

Published in: BMC cancer (2018)

CMEC and CMT cells shed exosomes in vitro that contain differentially expressed miRs. CMT exosomal RNA expresses a limited number of miRs that are up-regulated relative to CMEC, and these are predicted to target biologically relevant hormone receptors and oncogenic pathways. These results may inform future studies of circulating exosomes and the utility of miRs as biomarkers of breast cancer in women and dogs.

Keyphrases

mesenchymal stem cells
stem cells
transcription factor
induced apoptosis
polycystic ovary syndrome
cell cycle arrest
breast cancer risk
type diabetes
oxidative stress
bone marrow
pregnancy outcomes
adipose tissue
pregnant women
case control