Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis.

Sven GüntherJennifer BordenaveThong Hua-HuyCarole NiccoAmélie CumontRaphaël ThuilletLy TuTimothée QuatremarreThomas GuilbertGaël JalceFrédéric BatteuxMarc HumbertLaurent SavaleChristophe Guignabert Anh Tuan Dinh-Xuan

Published in: International journal of molecular sciences (2018)

Treatments with ISO-1 or compound 31 attenuates BLM-induced inflammation and fibrosis in lung, and prevents PH development in mice, suggesting that MIF is an important factor for IPF-PH development.

Keyphrases

pulmonary fibrosis
high glucose
diabetic rats
oxidative stress
type diabetes
endothelial cells
metabolic syndrome
mouse model
skeletal muscle