Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma.

Shuji NakamotoYusuke KumamotoKazuharu IgarashiYoshiki FujiyamaNobuyuki NishizawaShigenori EiHiroshi TajimaTakashi KaizuMasahiko WatanabeKeishi Yamashita

Published in: PloS one (2018)

Our study provided evidence that promoter DNA methylation of CDO1 gene could be an excellent molecular diagnostic and prognostic biomarker in primary EHCC. The combination of CDO1 methylation and preoperative serum CA19-9 effectively enriched EHCC patients who showed the most dismal prognosis. These markers would be beneficial for clinical clarification of the optimal strategies in EHCC.

Keyphrases

dna methylation
genome wide
copy number
gene expression
patients undergoing
transcription factor
single molecule
circulating tumor
protein kinase
cell free
nucleic acid