In vitro immunogenic profile of recombinant SARS-CoV2 S1-RBD peptide in murine macrophage and microglial cells.

Adriano José Maia Chaves FilhoPaloma Marinho JucáMichelle Verde Ramo SoaresCaio Andrade de OliveiraRaul Cavalcante de SousaDeniele Bezerra LósRemo Castro RussoJuliana Navarro Ueda YaochiteDanielle Silveira Macêdo

Published in: Memorias do Instituto Oswaldo Cruz (2023)

RBD peptide exposure has different effects depending on the cell line, exposure time, and concentration. This study brings new evidence about the immunogenic profile of RBD in macrophage and microglial cells, advancing the understanding of SARS-Cov2 immuno- and neuropathology.

Keyphrases

sars cov
induced apoptosis
cell cycle arrest
inflammatory response
respiratory syndrome coronavirus
neuropathic pain
oxidative stress
lps induced
endoplasmic reticulum stress
spinal cord injury
pi k akt