PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins.

Niina M SantioVeera VainioTuuli HoikkalaKwan Long MungMirka LångRiitta VahakoskiJustyna ZdrojewskaEleanor T CoffeyElena KremnevaEeva-Marja RainioPäivi J Koskinen

Published in: Cell communication and signaling : CCS (2020)

Our data suggest that PIM kinases are able to induce changes in actin dynamics to support cell adhesion and movement. Thus, we have identified a novel mechanism through which PIM kinases enhance motility and metastatic behaviour of cancer cells. Video abstract.

Keyphrases

cell adhesion
biofilm formation
prostate cancer
squamous cell carcinoma
small cell lung cancer
cell migration
electronic health record
big data
benign prostatic hyperplasia
pseudomonas aeruginosa
staphylococcus aureus
escherichia coli
cystic fibrosis
data analysis