MRI Visualization of Injectable Ureidopyrimidinone Hydrogelators by Supramolecular Contrast Agent Labeling.
Maarten H BakkerCheyenne C S TsengHenk M KeizerPeter R SeevinckHenk M JanssenFrebus J Van SlochterenSteven A J ChamuleauPatricia Y W DankersPublished in: Advanced healthcare materials (2018)
Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.
Keyphrases
- contrast enhanced
- hyaluronic acid
- drug delivery
- magnetic resonance imaging
- tissue engineering
- diffusion weighted
- magnetic resonance
- cancer therapy
- computed tomography
- diffusion weighted imaging
- wound healing
- pet imaging
- drug release
- heart failure
- ultrasound guided
- pet ct
- high resolution
- healthcare
- water soluble
- extracellular matrix
- electron microscopy
- molecularly imprinted