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ILC2s-Bipartisan politicians in cancer.

Abderezak ZebboudjMasataka AmisakiVinod P Balachandran
Published in: Science immunology (2022)
Group 2 innate lymphoid cells (ILC2s) are lymphocytes that both promote and suppress antitumor immunity. Jou and colleagues now report in colorectal tumorigenesis that the cytokine interleukin-25 activates ILC2s to induce myeloid cells that suppress antitumor immunity.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • nk cells
  • bone marrow
  • oxidative stress
  • signaling pathway
  • dendritic cells
  • acute myeloid leukemia
  • peripheral blood
  • immune response