Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction.
Matthew K BurrageMoritz HundertmarkLadislav ValkovičWilliam D WatsonJennifer J RaynerNikant Kumar SabharwalVanessa M FerreiraStefan NeubauerJack J J J MillerOliver J RiderAndrew J M LewisPublished in: Circulation (2021)
A gradient of myocardial energetic deficit exists across the spectrum of HFpEF. Even at low workload, this energetic deficit is related to markedly abnormal exercise responses in all 4 cardiac chambers, which is associated with detectable pulmonary congestion. The findings support an energetic basis for transient pulmonary congestion in HFpEF.