Stromal cell derived factor 1 plasmid to regenerate the anal sphincters.

Li SunAlanna BillupsAnna RietschMargot S DamaserMassarat Zutshi
Published in: Journal of tissue engineering and regenerative medicine (2022)
Eight weeks after a single or two doses of SDF-1injected into a chronic anal sphincter injury improved resting anal pressures and regenerated muscle in the entire defect. SDF-1 plasmid is effective in treating chronic defects of the anal sphincter in a large animal and could be clinically translated.