Brain Extract of Subacute Traumatic Brain Injury Promotes the Neuronal Differentiation of Human Neural Stem Cells via Autophagy.
Zhenghui HeLijian LangJiyuan HuiYuxiao MaChun YangWeiji WengJialin HuangXiongfei ZhaoXiaoqi ZhangQian LiangJiyao JiangJunfeng FengPublished in: Journal of clinical medicine (2022)
The subacute phase around 7 days after TBI in mice could be a candidate timepoint to encourage more neuronal differentiation after transplantation. The autophagy flux played a critical role in regulating neuronal differentiation of hNSCs and could serve as a potential target to improve the efficacy of transplantation in the early phase.
Keyphrases
- traumatic brain injury
- cerebral ischemia
- neural stem cells
- oxidative stress
- cell death
- endoplasmic reticulum stress
- endothelial cells
- signaling pathway
- cell therapy
- stem cells
- type diabetes
- subarachnoid hemorrhage
- severe traumatic brain injury
- high fat diet induced
- adipose tissue
- anti inflammatory
- induced pluripotent stem cells
- skeletal muscle