The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma.
Mariana Isadora Ribeiro VieiraMônica Versiani Nunes Pinheiro de QueirozMaria Borges Rabelo de SantanaHatilla Dos Santos SilvaAlmirane OliveiraCamila Alexandrina Viana de FigueiredoEduardo Martín Tarazona SantosRyan Dos Santos CostaLaura Maria de Lima Belizário Facury LasmarPublished in: Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia (2024)
In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.