Local T cell infiltrates are predominantly associated with corneal allograft rejection.

Justyna SakowskaPaulina GlasnerAnna Dukat-MazurekAnna RydzMaciej ZielińskiIrena PellowskaWojciech BiernatLeopold GlasnerKatarzyna Michalska-MałeckaPiotr Trzonkowski

Published in: Transplant immunology (2023)

PCTXs and especially RCTXs are rejected mainly by local T cells. The accumulation of effector CD4+ and CD8+ T cells, as well as CD4+ and CD8+ Tm cells is associated with the final rejection. Furthermore, local CD4+ and CD8+ Tregs expressing Foxp3 and Helios are probably insufficient to impose the acceptance of CTX.

Keyphrases

nk cells
oxidative stress
escherichia coli
dendritic cells
multidrug resistant
cell death
klebsiella pneumoniae
wound healing
pi k akt