Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.

Mingming TongToshiro SaitoPeiyong ZhaiShin-Ichi OkaWataru MizushimaMichinari Nakamura Shohei IkedaAkihiro ShirakabeJunichi Sadoshima

Published in: Circulation research (2021)

Ulk1-Rab9-dependent alternative mitophagy is activated during the chronic phase of HFD consumption and serves as an essential mitochondrial quality control mechanism, thereby protecting the heart against obesity cardiomyopathy.

Keyphrases

quality control
heart failure
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
high fat diet
atrial fibrillation
nlrp inflammasome
oxidative stress
body mass index