Desymmetrization of 1-Symmetrical Donor-Acceptor (D-A) Cyclopropanes via Reactions with 1,3-Cyclodiones.
Dongxin ZhangJunchao ZhongLei YinYan ChenJingjing ManQian-Feng ZhangPublished in: The Journal of organic chemistry (2020)
A new type of 1-unsymmetrical D-A cyclopropanes containing a cyclic enone motif was obtained by the desymmetrization of 1-symmetrical D-A cyclopropanes via first the Lewis acid-catalyzed O-nucleophilic ring-opening reaction with 1,3-cyclodiones followed by an organobase-promoted unexpected multistep intramolecular transformation.