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Approach to nutritional rickets.

Hüseyin Anil KorkmazRaja PadidelaBehzat Ozkan
Published in: Journal of pediatric endocrinology & metabolism : JPEM (2023)
Rickets is the disease of a growing skeleton and results from impaired apoptosis of hypertrophic chondrocytes and mineralization of the growth plate. Nutritionally induced rickets, secondary to vitamin D and/or calcium deficiency, remains a major global problem. In this review, we discuss pathogenesis, clinical signs, investigation and management of nutritional rickets.
Keyphrases
  • oxidative stress
  • endoplasmic reticulum stress
  • high glucose
  • cell cycle arrest
  • drug induced
  • extracellular matrix
  • replacement therapy
  • signaling pathway