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Drug-Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study.

Lisa Marie KieselAstrid BertscheWieland KiessManuela SiekmeyerThilo BertscheMartina Patrizia Neininger
Published in: Paediatric drugs (2024)
In a cohort of PICU patients, this study identified eight specific drug pairs involving high-alert medications that may increase the risk of interaction-associated symptoms, mainly hemodynamic alterations and electrolyte/fluid balance disturbances. If the administration of those drug pairs is unavoidable, patients should be closely monitored.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • emergency department
  • patient reported outcomes
  • young adults
  • clinical decision support
  • drug induced