Quest for Ideal Composite Biomarkers for Response to Immunotherapies.

Umang Swami Roberto H Nussenzveig Archana M Agarwal

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

In the CheckMate 275 study, composite biomarkers appear to better predict response to immunotherapy over individual ones. Nevertheless, the path forward needs consensus guidelines for biomarker interpretation. Thereafter, prospective validation with real-time, serial biospecimen collection along with the development of composite biomarker models leads to the goal of personalized therapy.See related article by Galsky et al., p. 5120.

Keyphrases

clinical practice
stem cells
mesenchymal stem cells
bone marrow
replacement therapy
drug induced