A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer.
E PangRong HuangShaojing ZhaoKe YangBaoling LiQiuxia TanSiyi TanMinhuan LanBenhua WangXiangzhi SongPublished in: Journal of materials chemistry. B (2022)
Phototherapeutic agents with near-infrared (NIR) fluorescence, strong reactive oxygen species generation and photothermal conversion capabilities are highly desirable for use in cancer therapy. Herein, a water-soluble NIR croconaine dye (TCR) with a thiophene-croconaine rigid core and two symmetric alkyl chains was designed and synthesized. TCR exhibits intense NIR absorption and fluorescence that peaked at 780 and 815 nm, respectively, with a high molar extinction coefficient of 1.19 × 10 5 M -1 cm -1 . Moreover, TCR has a high photothermal conversion efficiency of 77% and is capable of generating hydroxyl radicals (OH˙) under 735 nm laser irradiation. Based on these outstanding properties, TCR has proven its application in NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- water soluble
- cancer therapy
- regulatory t cells
- papillary thyroid
- reactive oxygen species
- drug delivery
- squamous cell
- single molecule
- highly efficient
- magnetic resonance imaging
- diffusion weighted imaging
- squamous cell carcinoma
- computed tomography
- lymph node metastasis
- magnetic resonance
- childhood cancer
- immune response
- radiation induced
- high speed
- quantum dots