Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells.

Sulaiman K MarafieEman M Al-ShawafJehad AbubakerHossein Arefanian

Published in: Biological research (2019)

In conclusion, our study suggests a novel regulatory involvement of FFAR1 in crosstalk with mTOR-Akt and IRS-1 signaling in β-cells under lipotoxic conditions.

Keyphrases

induced apoptosis
cell proliferation
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death