Alcohol consumption induces murine osteoporosis by downregulation of natural killer T-like cell activity.
Munehiro NaruoYasuyuki NegishiTakahisa OkudaMidori KatsuyamaKen OkazakiRimpei MoritaPublished in: Immunity, inflammation and disease (2021)
Our results indicate that the inactivation of innate immune cells, APCs, and NKT-like cells are likely to be crucial for alcohol-induced osteoporosis and provide a new therapeutic approach for preventing osteoporosis.
Keyphrases
- alcohol consumption
- postmenopausal women
- bone mineral density
- innate immune
- induced apoptosis
- cell cycle arrest
- single cell
- signaling pathway
- cell proliferation
- diabetic rats
- high glucose
- cell therapy
- oxidative stress
- body composition
- stem cells
- drug induced
- endoplasmic reticulum stress
- cell death
- bone marrow
- nk cells