Alcohol Feeding in Mice Promotes Colonic Hyperpermeability and Changes in Colonic Organoid Stem Cell Fate.
Christopher B ForysthMaliha ShaikhFaraz BishehsariGarth SwansonRobin M VoigtHemraj DodiyaPeter WilkinsonBeata SamelcoShiwen SongAli KeshavarzianPublished in: Alcoholism, clinical and experimental research (2017)
Data support a model for alcohol-induced colonic hyperpermeability via epigenetic effects on Notch1, and thus Hes1, suppression through a mechanism involving histone H3 deacetylation at the Notch1 locus. This decreased enterocyte and increased enteroendocrine cell colonic stem cell fate and decreased apical junctional proteins leading to hyperpermeability.
Keyphrases
- cell fate
- ulcerative colitis
- cell proliferation
- dna methylation
- gene expression
- single cell
- alcohol consumption
- electronic health record
- diabetic rats
- adipose tissue
- high glucose
- machine learning
- oxidative stress
- bone marrow
- stem cells
- endothelial cells
- mesenchymal stem cells
- skeletal muscle
- data analysis
- genome wide association study