Single Cell Genetic Profiling of Tumors of Breast Cancer Patients Aged 50 Years and Older Reveals Enormous Intratumor Heterogeneity Independent of Individual Prognosis.

Anna-Sophie LiegmannKerstin Heselmeyer-HaddadAnnette Lischka Daniela HirschWei-Dong ChenIrianna TorresTimo GemollAchim RodyChristoph ThornsEdward Michael GertzHendrik AlkemadeYue HuJens K HabermannThomas Ried

Published in: Cancers (2021)

Our results provide a comprehensive picture of genome instability profiles with a large variety of inter- and intratumor heterogeneity in breast cancer patients aged 50 years and older. In most cases, the distribution of chromosomal aneuploidies was consistent with previous results; however, striking exceptions, such as tumors driven by exclusive loss of chromosomes, were identified.

Keyphrases

single cell
rna seq
community dwelling
middle aged
high throughput
physical activity
genome wide
copy number
gene expression
dna methylation