The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.

Shane WiebeXiang Qi MengSung-Hoon KimXu ZhangJean-Claude LacailleArgel Aguilar-VallesNahum Sonenberg

Published in: Molecular autism (2020)

Together these results demonstrate an important role of 4EHP in regulating hippocampal plasticity and ASD-associated social behaviors, consistent with the link between mutations in GIGYF2 and ASD.

Keyphrases

autism spectrum disorder
healthcare
mental health
attention deficit hyperactivity disorder
cerebral ischemia
intellectual disability
depressive symptoms
temporal lobe epilepsy
sleep quality
working memory
subarachnoid hemorrhage