Serum and CSF brain damage markers NFL and GFAP correlate with tick-borne encephalitis disease severity - a multicenter study on Lithuanian and Swedish patients.
Malin VejeVytautas GriškaJolita PakalnieneAuksė MickienėDaniel BremellHenrik ZetterbergKaj BlennowLars LindquistMarie StudahlPublished in: European journal of neurology (2023)
Neuronal cell damage and astroglial cell activation with increased NFL and GFAP in CSF and serum were associated with a more severe disease, independent of age. Increased GFAP and NFL concentrations in CSF and NFL in serum were also indicative of spinal and/or cranial nerve damage. NFL and GFAP are promising prognostic biomarkers in TBE, and future studies should focus on determining the association between these biomarkers and long-term sequelae.
Keyphrases
- oxidative stress
- end stage renal disease
- single cell
- cell therapy
- chronic kidney disease
- newly diagnosed
- spinal cord
- peritoneal dialysis
- cerebrospinal fluid
- prognostic factors
- stem cells
- early onset
- multiple sclerosis
- resting state
- spinal cord injury
- current status
- bone marrow
- functional connectivity
- brain injury
- drug induced