Native Chemical Ligation at Serine Revisited.
Benoît SnellaVincent DiemerHervé DrobecqVangelis AgouridasOleg MelnykPublished in: Organic letters (2018)
Standard conditions for the formation of seryl-cysteinyl junctions by Native Chemical Ligation (NCL) can result in significant epimerization of the serine residue. Epimerization can be minimized to background level by adjusting peptide concentration and working at 4 °C.
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