Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts.

Chung-Te LiuShih-Chang HsuHui-Ling HsiehCheng-Hsien ChenChun-You ChenYuh-Mou SueTso-Hsiao ChenYung-Ho HsuFeng-Yen LinChun-Ming ShihYan-Ting ShiuPo-Hsun Huang

Published in: Molecular medicine (Cambridge, Mass.) (2022)

The results of this study indicate that mechanical disturbance in AVF activates β-catenin signaling to induce the transition of endothelial cells to myofibroblasts. This signaling cascade can be targeted to maintain AVF patency.

Keyphrases

endothelial cells
cancer therapy
type diabetes
high fat diet induced
drug delivery
vascular endothelial growth factor