Induction of immunogenic cell death in radiation-resistant breast cancer stem cells by repurposing anti-alcoholism drug disulfiram.
Ting SunWei YangSneh M TopraniWei GuoLile HeAlbert B DeLeoSoldano FerroneGong ZhangEnwen WangZunwen LinPan HuXinhui WangPublished in: Cell communication and signaling : CCS (2020)
DSF/Cu rendered IR-resistant BCSCs as sensitive as non-BCSCs to IR-induced ICD. Our data demonstrate the potential of IR and DSF/Cu to induce ICD in BCSCs and non-BCSCs leading to robust immune responses against not only differentiated/differentiating breast cancer cells but also BCSCs, the root cause of cancer formation, progression and metastasis.
Keyphrases
- cell death
- cancer stem cells
- immune response
- breast cancer cells
- papillary thyroid
- drug induced
- high glucose
- electronic health record
- big data
- oxidative stress
- diabetic rats
- magnetic resonance imaging
- squamous cell
- squamous cell carcinoma
- cell proliferation
- inflammatory response
- radiation therapy
- dendritic cells
- climate change
- signaling pathway
- deep learning