Prediction of Insufficient Beta-Lactam Concentrations in Extracorporeal Membranous Oxygenation Patients.
Amandine PolainJulie GorhamImmacolata RomeoBelliato MirkoLorenzo PelusoFrancesco PartipiloHassane NjimiAlexandre BrasseurFrederique JacobsJacques CreteurMaya HitesFabio Silvio TacconePublished in: Microorganisms (2021)
Insufficient broad-spectrum beta-lactam concentrations were observed in 12% of drug measurement during ECMO therapy. Higher than recommended drug regimens could be considered in the very early phase of therapy and in those patients with augmented renal clearance and with less severe organ dysfunction.
Keyphrases
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- extracorporeal membrane oxygenation
- drug induced
- acute respiratory distress syndrome
- emergency department
- gram negative
- adverse drug
- patient reported outcomes
- blood flow
- mesenchymal stem cells
- multidrug resistant
- electronic health record
- smoking cessation