Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating signal transduction. The mechanism of SFKs in various tumors has been widely studied, and there are more and more studies on its role in the kidney. Acute kidney injury (AKI) is a disease with complex pathogenesis, including oxidative stress (OS), inflammation, endoplasmic reticulum (ER) stress, autophagy, and apoptosis. In addition, fibrosis has a significant impact on the progression of AKI to developing chronic kidney disease (CKD). The mortality rate of this disease is very high, and there is no effective treatment drug at present. In recent years, some studies have found that SFKs, especially Src, Fyn, and Lyn, are involved in the pathogenesis of AKI. In this paper, the structure, function, and role of SFKs in AKI are discussed. SFKs play a crucial role in the occurrence and development of AKI, making them promising molecular targets for the treatment of AKI.
Keyphrases
- acute kidney injury
- oxidative stress
- cardiac surgery
- chronic kidney disease
- endoplasmic reticulum
- tyrosine kinase
- endoplasmic reticulum stress
- end stage renal disease
- cell death
- risk assessment
- dna damage
- emergency department
- ischemia reperfusion injury
- induced apoptosis
- cardiovascular disease
- cardiovascular events
- coronary artery disease
- diabetic rats
- peritoneal dialysis
- combination therapy
- adverse drug
- heat shock
- drug induced