Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.

Kevin NiAmar GillVictor TsengAndrew M MikoszKengo KoikeErica L BeatmanCassie Y XuDanting CaoFabienne GallyKara J MouldKarina A SerbanKelly S SchweitzerKeith L MarchWilliam J JanssenEva Nozik-GrayckStavros GarantziotisIrina Petrache

Published in: Respiratory research (2018)

Respiratory infection induces rapid HC modification of HA followed by fragmentation and clearance, with kinetics that parallel the onset and resolution phase of ALI, respectively. Alveolar macrophages may be an important source of pulmonary TSG-6 required for HA remodeling. The formation of HC-modified HA had a minor role in the onset, severity, or resolution of experimental reversible ALI induced by respiratory infection with gram-negative bacteria.

Keyphrases

single molecule
pulmonary hypertension
lipopolysaccharide induced
loop mediated isothermal amplification
lps induced
respiratory tract
inflammatory response