A novel colorectal cancer test combining microsatellite instability and BRAF/RAS analysis: Clinical validation and impact on Lynch syndrome screening.

Richard GallonPatricia Herrero-BelmonteRachel PhelpsChristine HayesElizabeth SollarsDaniel EganHelena SpiewakSam NaltySarah MillsPeh Sun LooGillian M BorthwickMauro Santibanez-KorefJohn BurnCiaron McAnultyMichael S Jackson

Published in: BJC reports (2024)

A novel amplicon-sequencing assay of CRCs, including all biomarkers for LS screening and anti-EGFR therapy, achieved >95% testing rate. Adoption of this low cost, scalable, and fully automatable test will complement on-going, national initiatives to improve LS screening.

Keyphrases

low cost
small cell lung cancer
quality improvement
high throughput
epidermal growth factor receptor
tyrosine kinase
stem cells
wild type
single cell
case report
bone marrow