RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma.

Nianwu Wang Wei Wang Wenli Mao Nazuke Kuerbantayi Nuan Jia Yan Chen Fang Zhou Li Yin Yukun Wang

Published in: BioMed research international (2021)

11 hub genes in four hub gene modules (LY86, ACTR2, CDK2, CKAP4, KPNB1, RBBP4, SMAD4, MYL6, RPS27, TSPAN2, and VAMP2) were chosen as the significant hub genes. Through the GO function enrichment analysis, it was indicated that four modules were abundant in immune system functions (floralwhite), amino acid biosynthetic process (lightpink4), cell chemotaxis (navajowhite2), and targeting protein (paleturquoise). Four hub genes with the highest |GS| were verified by prognostic analysis.

Keyphrases

bioinformatics analysis
network analysis
genome wide
genome wide identification
amino acid
genome wide analysis
gene expression
squamous cell carcinoma
stem cells
drug delivery
radiation therapy
binding protein
locally advanced
cell proliferation
mesenchymal stem cells
rectal cancer