Mechanisms Regulating Muscle Protein Synthesis in CKD.

Liping ZhangQin ChenZihong ChenYing WangJorge L GamboaTalat Alp Ikizler Giacomo GaribottoWilliam E Mitch

Published in: Journal of the American Society of Nephrology : JASN (2020)

CKD suppresses muscle protein synthesis via epigenetic mechanisms that NO66 mediates. Blocking NO66 could suggest strategies that counter CKD-induced abnormal muscle protein catabolism.

Keyphrases

chronic kidney disease
skeletal muscle
gene expression
dna methylation
high glucose
signaling pathway
diabetic rats
drug induced
protein protein