Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance.

Vasiliki PelekanouDaniel E Carvajal-HausdorfMehmet AltanBrad WassermanCristobal Carvajal-HausdorfHallie WimberlyJason BrownDonald LanninLajos PusztaiDavid L Rimm

Published in: Breast cancer research : BCR (2017)

Increase in stromal TILs in residual cancer compared to pretreatment tissue is associated with improved recurrence-free survival. Despite a trend for increasing TIL counts, PD-L1 expression decreased in residual disease compared to pretreatment samples.

Keyphrases

free survival
neoadjuvant chemotherapy
locally advanced
peripheral blood
lymph node
sentinel lymph node
papillary thyroid
bone marrow
childhood cancer
rectal cancer
lymph node metastasis
early stage