β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through phosphoenolpyruvate carboxykinase and insulin pathway in zebrafish in-vivo larval model.
Ajay GuruGokul SudhakaranMikhlid H AlmutairiBader O AlmutairiAnnie JulietJesu Arockia RajPublished in: Molecular biology reports (2022)
Overall, the findings indicate that WL15 of cysteine and glycine-rich protein 2 can act as a potential antioxidant for type 2 diabetes patients in respect of improving β-cell regeneration.
Keyphrases
- oxidative stress
- type diabetes
- induced apoptosis
- stem cells
- diabetic rats
- single cell
- end stage renal disease
- cell therapy
- ejection fraction
- glycemic control
- chronic kidney disease
- newly diagnosed
- protein protein
- dna damage
- ischemia reperfusion injury
- cell cycle arrest
- skeletal muscle
- small molecule
- binding protein
- living cells
- metabolic syndrome
- patient reported outcomes
- insulin resistance
- mesenchymal stem cells
- risk assessment
- anti inflammatory
- human health
- aedes aegypti