ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling.

Xinyang YuPrashant K SinghShamira TabrejeeSatrajit SinhaMichael J Buck

Published in: Epigenetics & chromatin (2021)

Overall, our results demonstrate that ΔNp63 is a pioneer factor that binds nucleosome edges at inaccessible and unmodified chromatin sites and induces histone acetylation and nucleosome repositioning.

Keyphrases

dna damage
gene expression
transcription factor
genome wide
dna methylation