MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer.

Sanjeev Kumar SrivastavaMohammad Aslam KhanShashi AnandHaseeb ZubairSachin Kumar DeshmukhGirijesh Kumar PatelSeema SinghJoel AndrewsBin WangJames Elliot CarterAjay Pratap Singh

Published in: British journal of cancer (2021)

Our findings reveal a novel MYB-AR crosstalk in PCa and establish its role in castration resistance.

Keyphrases

prostate cancer
transcription factor
radical prostatectomy
single cell