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Autophagy Function and Benefits of Autophagy Induction in Models of Spinocerebellar Ataxia Type 3.

Maxinne WatchonLuan LuuStuart K PlenderleithKristy C YuanAngela S Laird
Published in: Cells (2023)
We propose that signs of autophagy impairment occur in the SH-SY5Y model of SCA3 and SCA3 zebrafish at larval and advanced age stages. Treatment of the larval SCA3 zebrafish with various compounds with autophagy induction capacity was able to produce the improved swimming of the zebrafish, suggesting the potential benefit of autophagy-inducing compounds for the treatment of SCA3.
Keyphrases
  • aedes aegypti
  • zika virus
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • climate change
  • smoking cessation