Impact of Antioxidant Therapy on Natural Pregnancy Outcomes and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ashok AgarwalRossella CannarellaRamadan SalehAhmed M HarrazHussein KandilGianmaria SalvioFlorence BoitrelleShinnosuke KurodaAla'a FarkouhAmarnath RambhatlaArmand ZiniGiovanni M Colpi ForumMurat GulParviz K KavoussiTaha Abo-Almagd Abdel-Meguid HamodaEdmund Y KoGökhan ÇalıkTuncay ToprakGermar-Michael PinggeraHyun Jun ParkRamy Abou GhaydaSukhbinder MinhasGian Maria BusettoMustafa Emre BakırcıoğluAtes KadiogluEric ChungGiorgio Ivan RussoAldo Eugenio CalogeroRafael Favero AmbarChanna N JayasenaRupin ShahPublished in: The world journal of men's health (2022)
The present analysis upgrades the level of evidence favoring a recommendation for using AOX in male infertility to improve the spontaneous pregnancy rate and the conventional sperm parameters. The failure to demonstrate an increase in live-birth rate, despite an increase in pregnancy rates, is due to the very few RCTs specifically assessing the impact of AOX on live-birth rate. Therefore, further RCTs assessing the impact of AOX on live-birth rate and miscarriage rate, and SDF will be helpful.