Neuropathological and biochemical investigation of Hereditary Ferritinopathy cases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress.
Marzena Kurzawa-AkanbiM KeoghE TsefouL RamsayM JohnsonS KeersL Wsa OchiengA McNairP SinghA KhanA PyleG HudsonP G InceJ AttemsJ BurnP F ChinneryC M MorrisPublished in: Neuropathology and applied neurobiology (2020)
HF shows hallmarks of a protein aggregation disorder, in addition to iron accumulation. Degeneration in HF is not accompanied by age-related neurodegenerative pathology and the lack of evidence of oxidative stress and mitochondrial damage suggests that these are not key mediators of neurodegeneration in HF, casting light on other neurodegenerative diseases characterized by iron deposition.