METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.

Meilin XueLei DongHonghai ZhangYangchan LiKangqiang QiuZhicong ZhaoMin GaoLi HanAnthony K N ChanWei LiKeith LeungKitty WangSheela Pangeni PokharelYing QingWei LiuXueer WangLili RenHongjie BiLu YangChao ShenZhenhua ChenLaleh MelstromHongzhi LiNikolai TimchenkoXiaolan DengWendong HuangSteven T RosenJingyan TianLin XuJiajie DiaoChun-Wei ChenJianjun ChenBaiyong ShenHao ChenRui Su

Published in: Journal of hematology & oncology (2024)

Our findings highlight the crucial oncogenic role of METTL16 in promoting HCC pathogenesis and enhancing liver CSC self-renewal through augmenting mRNA translation efficiency.

Keyphrases

cancer stem cells
binding protein
transcription factor