Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.

Mikko KarpaleAki Juhani KäräjämäkiOuti KummuHelena GyllingTuulia HyötyläinenMatej OrešičAri TolonenHeidi HautajärviMarkku J SavolainenMika Ala-KorpelaJanne Hukkanen Jukka Hakkola

Published in: British journal of pharmacology (2021)

PXR activation induces cholesterol synthesis, elevating LDL and total cholesterol in humans. The PXR-SREBP2 pathway is a novel regulator of the cholesterol and PCSK9 synthesis and a molecular mechanism for drug- and chemical-induced hypercholesterolemia.

Keyphrases

low density lipoprotein
drug induced
high glucose
diabetic rats
transcription factor
type diabetes
emergency department
cardiovascular disease