Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence.

Lasse RuokolainenNanna FyhrquistTiina LaatikainenPetri AuvinenVittorio FortinoGiovanni ScalaPekka JousilahtiPiia KarisolaJohanna VendelinAntti KarkmanOlga MarkelovaMika J MäkeläSari LehtimäkiJoseph NdikaNoora OttmanLaura PaalanenLars PaulinErkki VartiainenLeena von HertzenDario GrecoTari HaahtelaHarri Alenius

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Young populations living in the Finnish and Russian Karelia show marked differences in genome-wide gene expression and host contrasting skin and nasal epithelium microbiota. The rich gene-microbe network in Russians seems to result in a better-balanced innate immunity and associates with low allergy prevalence.

Keyphrases

genome wide
gene expression
dna methylation
risk factors
middle aged
copy number
infectious diseases
transcription factor
genetic diversity