ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1.

Yaru ChenJiawei ZhouShang WuLei WangGaogui ChenDake ChenXianwen PengYi-Liang MiaoShuqi MeiFenge Li

Published in: Cell & bioscience (2023)

Taken together, the present study demonstrates that covalent ISG15 conjugation produces a novel regulatory axis of ISG15-ADAMTS1 that enhances the degradation of ADAMTS1, thereby compromising ovulation and female fertility.

Keyphrases

polycystic ovary syndrome
signaling pathway
transcription factor
type diabetes
insulin resistance