Login / Signup

Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya.

Amin S HassanDavid F BibbyShalton M MwaringaClara A AgutuKennedy K NdiranguEduard J SandersPatricia A CaneJean L MbisaJames Alexander Berkley
Published in: PloS one (2019)
Using NGS, pre-treatment resistance variants were common, though observed PI variants were unlikely transmitted, but rather probably generated de novo. Even when detected from a low frequency, pre-treatment NRTI and/or NNRTI resistance variants may adversely affect treatment outcomes.
Keyphrases
  • copy number
  • hepatitis c virus
  • antiretroviral therapy
  • climate change
  • hiv infected
  • gene expression
  • human immunodeficiency virus
  • combination therapy
  • risk assessment
  • dna methylation
  • south africa