Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from rural coastal Kenya.
Amin S HassanDavid F BibbyShalton M MwaringaClara A AgutuKennedy K NdiranguEduard J SandersPatricia A CaneJean L MbisaJames Alexander BerkleyPublished in: PloS one (2019)
Using NGS, pre-treatment resistance variants were common, though observed PI variants were unlikely transmitted, but rather probably generated de novo. Even when detected from a low frequency, pre-treatment NRTI and/or NNRTI resistance variants may adversely affect treatment outcomes.